The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a little soluble in alcohol. The molecular weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's got the next chemical construction.

Usually do not utilize a family teaspoon to measure your medicine. You could possibly unintentionally acquire an excessive amount of. You'll be able to question your pharmacist for the measuring gadget it is best to use and how to measure the correct dose.

Your Health care supplier may perhaps do blood tests to look for adrenal gland problems. Simply call your Health care supplier right away Should you have any of those indicators:

It's not at all regarded no matter if Promethazine HCl is excreted in human milk. Due to the fact several medicine are excreted in human milk and as a result of opportunity for serious adverse reactions in nursing infants from Promethazine HCl Oral Remedy, a call must be manufactured no matter whether to discontinue nursing or to discontinue the drug, taking into consideration the necessity of the drug towards the mother.

Promethazine is metabolized via the liver to several different compounds; the sulfoxides of Promethazine and N-demethylpromethazine are classified as the predominant metabolites showing up during the urine.

Codeine: Dosage of codeine SHOULD NOT BE Greater if cough fails to respond; an unresponsive cough must be reevaluated in five days or sooner for attainable underlying pathology, such as foreign body or lessen respiratory tract ailment.

Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Alternative should not be increased if cough fails to reply; an unresponsive cough need to be reevaluated in five days or sooner for feasible underlying pathology, including overseas human body or decreased respiratory tract ailment [see Dosage and Administration (2.three)].

Recommend clients to normally use an accurate milliliter measuring unit when measuring and administering Promethazine HCl and Codeine Phosphate Oral Solution. Advise sufferers that a domestic teaspoon just isn't an exact measuring system and these types of use could lead on to overdosage and severe adverse reactions [see Overdosage (10)].

are pregnant or approach to be pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Solution can damage your unborn newborn. See “What exactly is The most crucial details I should really know about Promethazine Hydrochloride and Codeine Phosphate Oral Remedy?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and could potentially cause severe Uncomfortable side effects with your newborn including enhanced sleepiness, respiration issues (respiratory melancholy), and Dying. It is not known if promethazine can move into your breast milk.

Promethazine HCl happens like a white to faint yellow, pretty much odorless, crystalline powder which little by little oxidizes and turns blue on prolonged exposure to air. It truly is freely soluble in drinking water and soluble in alcohol.

Thing to consider needs to be given on the discontinuation of Promethazine HCl also to using other medication if these reactions come about. Respiratory depression, nightmares, delirium, and agitated conduct have also been reported in A few of these clients.

Promethazine can be a phenothiazine derivative which differs structurally within the antipsychotic phenothiazines from the existence of a branched side chain and no ring substitution.

Correct assessment of your individual, good prescribing methods, periodic re-analysis of therapy, and get more info good dispensing and storage are proper measures that enable to limit abuse of opioid medicine.

Sedation in both young children and Grown ups, in addition to aid of apprehension and manufacture of light slumber from which the client is often quickly aroused.